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Article

A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.

Scientific reports - 31 Mar 2022

Egger Tom, Bordignon Benoît, Coquelle Arnaud

Abstract excerpt

Colorectal cancer (CRC) ranks third among the most frequent malignancies and represents the second most common cause of cancer-related deaths worldwide. By interfering with the DNA replication process of cancer cells, several chemotherapeutic molecules used in CRC therapy induce replication stress (RS). At the cellular level, this stress is managed by the ATR-CHK1 pathway, which activates the replication...

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Identifiers

PMID: 35361811
DOI: 10.1038/s41598-022-09308-4
PMCID: PMC8971416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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