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Article

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

23 Feb 2015

Abstract excerpt

The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2 (CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase (ATR)/CHEK1 (best known as CHK1) cascades are the 2 major signaling pathways driving the DNA damage response (DDR), a network of processes crucial for the preservation of genomic stability that act as a barrier against tumorigenesis and tumor...

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PMID: 27308506
DOI: 10.1080/23723556.2015.1012976

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