Article

The DNA damage response to ATR inhibition

2021-01-01

Abstract excerpt

The protein kinase ATR is an apical regulator of the DNA damage response and coordinates DNA repair, cell cycle checkpoint engagement, and DNA replication to ensure genome stability. To achieve this, ATR signalling often cooperates with, or antagonises, other DNA repair pathways, including many known and predicted interplays with the related kinase ATM. Accordingly, ATR inhibitors (ATRi) are in clinical developmen...

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Literature Corpus work: 1acffeef-7a68-5cf6-bece-f28adc7acca4
DOI: 10.17863/cam.74415

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