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Article

ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage

29 Jan 2018

Abstract excerpt

G/T lesion recognition by MMR initiates mismatch excision, the reinsertion of a mismatched thymidine during resynthesis could initiate futile repair cycles. One consequence of futile repair cycles might be a disruption of overall DNA replication in the affected cell. Herein, we show that in MMR-proficient HeLa cancer cells, treatment with a DNA alkylating agent slows S phase progression, yet cells still progress...

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PMID: 29378956
DOI: 10.1073/pnas.1720355115

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