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Article

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

8 Jun 2021

Abstract excerpt

Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and represents a potential target for cancer therapies. ATRX is known to function as a histone chaperone that helps incorporate histone variant, H3.3, into the genome. Studies have implicated ATRX in key DNA damage response (DDR) pathways but a distinct role in DNA repair has yet to be fully elucidated. To further...

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PMID: 34118569
DOI: 10.1016/j.tranon.2021.101147

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