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Article

Targeting the ATR-CHK1 Axis in Cancer Therapy

27 Apr 2017

Abstract excerpt

Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that shows great promise for tumour selectivity. Key components of the DDR are the ataxia telangiectasia mutated and Rad3 related (ATR) and checkpoint kinase 1 (CHK1) kinases. This review article describes the role of ATR and its major downstream target, CHK1, in the DDR and why cancer cells are particularly reliant on the ATR-CHK1...

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Identifiers

PMID: 28448462
DOI: 10.3390/cancers9050041

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