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Article

Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance.

Cancer research - 15 Aug 2005

Lewis Kriste A, Mullany Sally, Thomas Bijoy, Chien Jeremy, Loewen Ralitsa, Shridhar Viji, Cliby William A

Abstract excerpt

ATR (ataxia telangiectasia and Rad3-related) function is necessary for the proper response to commonly used chemotherapeutic agents. Heterozygous truncating mutations in exon 10 of the ATR gene have been described in numerous cancers exhibiting microsatellite instability. We show that truncating mutations of ATR are capable of acting in a dominant-negative manner to abrogate ATR-dependent Chk1 phosphorylation and...

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Source

Identifiers

PMID: 16103057
DOI: 10.1158/0008-5472.CAN-05-1019

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance.PMID 16103057Read ↗

ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.Semantic proximity Read ↗

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.Semantic proximity Read ↗

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.Semantic proximity Read ↗

The DNA damage response to ATR inhibitionSemantic proximity Read ↗

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.Semantic proximity Read ↗

Reduced ATR or Chk1 Expression Leads to Chromosome Instability and Chemosensitization of Mismatch Repair–deficient Colorectal Cancer CellsSemantic proximity Read ↗

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation.Semantic proximity Read ↗

Targeting the ATR-CHK1 Axis in Cancer TherapySemantic proximity Read ↗

Assessing the prognostic role of ATR mutation in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study.Semantic proximity Read ↗

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agentsSemantic proximity Read ↗

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