Article
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
The Journal of clinical investigation - 1 Sept 2009
Fu Zheng, Regan Kevin, Zhang Lizhi, Muders Michael H, Thibodeau Stephen N, French Amy, Wu Yanhong, Kaufmann Scott H, Lingle Wilma L, Chen Junjie, Tindall Donald J
Abstract excerpt
Genetic instability, which leads to an accumulation of various genetic abnormalities, has been considered an essential component of the human neoplasic transformation process. However, the molecular basis of genomic instability during tumorigenesis remains incompletely understood. Growing evidence indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitotic checkpoint...
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