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Article

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Avdievich Elena, Reiss Cora, Scherer Stefan J, Zhang Yongwei, Maier Sandra M, Jin Bo, Hou Harry, Rosenwald Andreas, Riedmiller Hubertus, Kucherlapati Raju, Cohen Paula E, Edelmann Winfried, Kneitz Burkhard

Abstract excerpt

Mutations in the human DNA mismatch repair (MMR) gene MLH1 are associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome, HNPCC) and a significant proportion of sporadic colorectal cancer. The inactivation of MLH1 results in the accumulation of somatic mutations in the genome of tumor cells and resistance to the genotoxic effects of a variety of DNA damaging agents. To study the effect of MLH1...

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Identifiers

PMID: 18337503
DOI: 10.1073/pnas.0800276105
PMCID: PMC2393764

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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