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Article

Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins.

Scientific reports - 29 Aug 2017

Muñoz-Soriano Verónica, Domingo-Muelas Ana, Li Tianlu, Gamero Esther, Bizy Alexandra, Fariñas Isabel, Alepuz Paula, Paricio Nuria

Abstract excerpt

Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin...

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Identifiers

PMID: 28852021
DOI: 10.1038/s41598-017-10057-y
PMCID: PMC5575014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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