Article
VASA mediates translation through interaction with a Drosophila yIF2 homolog.
Molecular cell - 1 Jan 2000
Carrera P, Johnstone O, Nakamura A, Casanova J, Jäckle H, Lasko P
Abstract excerpt
The Drosophila gene vasa (vas) encodes an RNA-binding protein required for embryonic patterning and germ cell specification. In vas mutants, translation of several germline mRNAs is reduced. Here we show that VAS interacts directly with the Drosophila homolog of yeast translation initiation factor 2, encoded by a novel gene, dIF2. Embryos produced by vas/+; dIF2/+ females have pattern defects and fewer germline...
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