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Article

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.

Developmental biology - 15 Jan 2008

Clouse K Nicole, Ferguson Scott B, Schüpbach Trudi

Abstract excerpt

During Drosophila melanogaster oogenesis, the proper localization of gurken (grk) mRNA and protein is required for the establishment of the dorsal-ventral axis of the egg and future embryo. Squid (Sqd) is an RNA-binding protein that is required for the correct localization and translational regulation of the grk message. We show that Cup and polyA-binding protein (PABP) interact physically with Sqd and with each...

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Identifiers

PMID: 18082158
DOI: 10.1016/j.ydbio.2007.11.008
PMCID: PMC2276622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.PMID 18082158Read ↗

Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis.Semantic proximity Read ↗

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.Semantic proximity Read ↗

Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Semantic proximity Read ↗

Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.Semantic proximity Read ↗

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.Semantic proximity Read ↗

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.Semantic proximity Read ↗

The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.Semantic proximity Read ↗

Cup regulates oskar mRNA stability during oogenesis.Semantic proximity Read ↗

Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.Semantic proximity Read ↗

The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization.Semantic proximity Read ↗

Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.Semantic proximity Read ↗

Glorund interactions in the regulation of gurken and oskar mRNAs.Semantic proximity Read ↗

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