Article
eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.
Plant physiology - 1 Sept 2016
Bush Maxwell S, Pierrat Olivier, Nibau Candida, Mikitova Veronika, Zheng Tao, Corke Fiona M K, Vlachonasios Konstantinos, Mayberry Laura K, Browning Karen S, Doonan John H
Abstract excerpt
Eukaryotic initiation factor 4A (eIF4A) is a highly conserved RNA-stimulated ATPase and helicase involved in the initiation of messenger RNA translation. Previously, we found that eIF4A interacts with cyclin-dependent kinase A (CDKA), the plant ortholog of mammalian CDK1. Here, we show that this interaction occurs only in proliferating cells where the two proteins coassociate with 5'-cap-binding protein...
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