Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.

Genes and immunity - 1 Mar 2014

Dugas V, Liston A, Hillhouse E E, Collin R, Chabot-Roy G, Pelletier A-N, Beauchamp C, Hardy K, Lesage S

Abstract excerpt

Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Antigens
Share to CD8 Antigens
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Count

Share to Mice, Inbred CBA

Share to Mice, Inbred NOD

Share to Mice, Transgenic

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 24335706
DOI: 10.1038/gene.2013.65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.PMID 24335706Read ↗

Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.Semantic proximity Read ↗

Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.Semantic proximity Read ↗

A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells.Semantic proximity Read ↗

Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.Semantic proximity Read ↗

Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.Semantic proximity Read ↗

Evidence of genetic epistasis in autoimmune diabetes susceptibility revealed by mouse congenic sublines.Semantic proximity Read ↗

Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.Semantic proximity Read ↗

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.