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Article

Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5.

Diabetes - 1 Jan 2012

Hamilton-Williams Emma E, Cheung Jocelyn, Rainbow Daniel B, Hunter Kara M, Wicker Linda S, Sherman Linda A

Abstract excerpt

Type 1 diabetes genes within the interleukin (IL)-2, cytotoxic T-lymphocyte--associated protein 4 (CTLA-4), and natural resistance-associated macrophage protein (NRAMP1) pathways influence development of autoimmune diabetes in humans and NOD mice. In NOD mice, when present together, protective alleles encoding IL-2, Idd3 candidate gene, CTLA-4, NRAMP1, and acetyl-coenzyme A dehydrogenase, long-chain (ACADL)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22106155
DOI: 10.2337/db11-0790
PMCID: PMC3237671

Genes

ACADL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5.PMID 22106155Read ↗

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Semantic proximity Read ↗

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