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Article

Idd1 and Idd3 are necessary but not sufficient for development of type 1 diabetes in NOD mouse.

Diabetes research and clinical practice - 1 Dec 2004

Ikegami Hiroshi, Fujisawa Tomomi, Sakamoto Tsutomu, Makino Susumu, Ogihara Toshio

Abstract excerpt

Type 1 diabetes in the NOD mouse is under polygenic control, with a major susceptibility gene, Idd1, in the major histocompatibility complex (MHC). To investigate the contribution of the NOD MHC to type 1 diabetes susceptibility, a B6.NOD-H-2 congenic strain, in which the NOD MHC was introgressed onto the genetic background of the C57BL/6 strain, was established. Despite possession of the diabetogenic MHC from...

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PMID: 15563987
DOI: 10.1016/j.diabres.2003.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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