Crystal structure of the bacterial nucleoside transporter Tsx.

Abstract excerpt

Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial Outer Membrane Proteins
• Share to Crystallography, X-Ray
• Share to Escherichia coli Proteins