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Article

Insight into the mechanism of H+-coupled nucleobase transport.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2023

Weng Jun, Zhou Xiaoming, Wiriyasermkul Pattama, Ren Zhenning, Chen Kehan, Gil-Iturbe Eva, Zhou Ming, Quick Matthias

Abstract excerpt

Members of the nucleobase/ascorbic acid transporter (NAT) gene family are found in all kingdoms of life. In mammals, the concentrative uptake of ascorbic acid (vitamin C) by members of the NAT family is driven by the Na+ gradient, while the uptake of nucleobases in bacteria is powered by the H+ gradient. Here, we report the structure and function of PurTCp, a NAT family member from Colwellia psychrerythraea. The...

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Identifiers

PMID: 37549264
DOI: 10.1073/pnas.2302799120
PMCID: PMC10438392

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