Article
Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.
Molecular microbiology - 1 Oct 2015
Karena Ekaterini, Tatsaki Ekaterini, Lambrinidis George, Mikros Emmanuel, Frillingos Stathis
Abstract excerpt
The xanthine permease XanQ of Escherichia coli is a paradigm for transporters of the evolutionarily broad family nucleobase-cation symporter-2 (NCS2) that transport key metabolites or anti-metabolite analogs. Most functionally known members are xanthine/uric acid transporters related to XanQ and belong to a distinct phylogenetic cluster of the family. Here, we present a comprehensive mutagenesis of XanQ based on...
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