Article
Single amino acid substitutions affecting the substrate specificity of the Escherichia coli K-12 nucleoside-specific Tsx channel.
The Journal of biological chemistry - 15 Aug 1993
Fsihi H, Kottwitz B, Bremer E
Abstract excerpt
The Tsx protein from the Escherichia coli outer membrane is a channel-forming protein containing a nucleoside-specific binding site. The antibiotic albicidin enters the cell via this substrate-specific channel. Because albicidin is toxic for E. coli at a very low external substrate concentration,...
Topics
- Amino Acids
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Base Sequence
- Coliphages
- DNA, Bacterial
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Escherichia coli Proteins
- Kinetics
- Molecular Sequence Data
- Mutation
- Nucleosides
- Organic Chemicals
- Receptors, Virus
- Xanthomonas