Substrate selectivity of YgfU, a uric acid transporter from Escherichia coli.

doi:10.1074/jbc.M112.355818

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Article

Substrate selectivity of YgfU, a uric acid transporter from Escherichia coli.

The Journal of biological chemistry - 4 May 2012

Papakostas Konstantinos, Frillingos Stathis

Abstract excerpt

The ubiquitous nucleobase-ascorbate transporter (NAT/NCS2) family includes more than 2,000 members, but only 15 have been characterized experimentally. Escherichia coli has 10 members, of which the uracil permease UraA and the xanthine permeases XanQ and XanP are functionally known. Of the remaining members, YgfU is closely related in sequence and genomic locus with XanQ. We analyzed YgfU and showed that it is a...

Topics

Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Biological Transport
Blotting, Western
Escherichia coli Proteins
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Nucleobase Transport Proteins
Protein Structure, Secondary
Sequence Homology, Amino Acid
Uric Acid
Xanthine

Source

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Identifiers

PMID: 22437829
DOI: 10.1074/jbc.M112.355818
PMCID: PMC3346081

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