Article

NAT/NCS2-hound: A Webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase–cation symporters of the NAT/NCS2 family

2018-05-28

Abstract excerpt

Nucleobase transporters are important for supplying the cell with purines and/or pyrimidines, for controlling the intracellular pool of nucleotides and for obtaining exogenous nitrogen/carbon sources for the metabolism. Nucleobase transporters are also evaluated as potential targets for antimicrobial therapies, since several pathogenic microorganisms rely on purine/pyrimidine salvage from their hosts. The majority...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a306790a-4c2b-586c-b261-dad33e3164ab
DOI: 10.1101/332452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NAT/NCS2-hound: A Webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase–cation symporters of the NAT/NCS2 familyDOI 10.1101/332452Read

Origin, diversification and substrate specificity in the family of NCS1/FUR transporters.Semantic proximity Read

Phylogenetic Diversity of NTT Nucleotide Transport Proteins in Free-Living and Parasitic Bacteria and EukaryotesSemantic proximity Read

Tapping the nucleotide pool of the host: novel nucleotide carrier proteins of <i>Protochlamydia amoebophila</i>Semantic proximity Read

Comparative and functional analysis of the widely occurring family of Nep1-like proteins.Semantic proximity Read

Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.Semantic proximity Read

The Transporter Classification Database (TCDB): recent advancesSemantic proximity Read

Bioinformatic Characterization of P-Type ATPases Encoded Within the Fully Sequenced Genomes of 26 EukaryotesSemantic proximity Read

Insight into the mechanism of H+-coupled nucleobase transport.Semantic proximity Read

BacARscan: A Comprehensive and Interactive Web-Resource to Discern Antibiotic Resistance Gene Diversity in –Omics DatasetsSemantic proximity Read

Characterization of the apicomplexan amino acid transporter (ApiAT) family in <i>Toxoplasma gondii</i>Semantic proximity Read

Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistanceSemantic proximity Read

Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter.Semantic proximity Read