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The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region.

Blood - 1 Dec 2004

Goyama Susumu, Yamaguchi Yuko, Imai Yoichi, Kawazu Masahito, Nakagawa Masahiro, Asai Takashi, Kumano Keiki, Mitani Kinuko, Ogawa Seishi, Chiba Shigeru, Kurokawa Mineo, Hirai Hisamaru

Abstract excerpt

Acute myelogenous leukemia 1 (AML1; runt-related transcription factor 1 [Runx1]) is a member of Runx transcription factors and is essential for definitive hematopoiesis. Although AML1 possesses several subdomains of defined biochemical functions, the physiologic relevance of each subdomain to hematopoietic development has been poorly understood. Recently, the consequence of carboxy-terminal truncation in AML1 was...

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Identifiers

PMID: 15271791
DOI: 10.1182/blood-2004-04-1535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region.PMID 15271791Read ↗

Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.Semantic proximity Read ↗

The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.Semantic proximity Read ↗

VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic developmentSemantic proximity Read ↗

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signalingSemantic proximity Read ↗

Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1Semantic proximity Read ↗

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.Semantic proximity Read ↗

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Semantic proximity Read ↗

Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.Semantic proximity Read ↗

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cellsSemantic proximity Read ↗

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cellsSemantic proximity Read ↗

Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.Semantic proximity Read ↗

R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways.Semantic proximity Read ↗

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