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Article

Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Taoudi Samir, Medvinsky Alexander

Abstract excerpt

The first definitive/adult-type hematopoietic stem cells (HSCs) in the mouse aorta-gonad-mesonephros region emerge between embryonic days 10.5 and 11.5. The discovery of clusters of hematopoietic cells on the ventral luminal surface of the dorsal aorta in various vertebrate species has led to speculation that the floor of the dorsal aorta may play an essential role for the development of the definitive...

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Identifiers

PMID: 17517650
DOI: 10.1073/pnas.0700984104
PMCID: PMC1890506

Genes

PECAM1

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