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Article

Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1

9 May 2007

Abstract excerpt

BACKGROUND: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear. Here we investigate whether altering relative expression of AML1 isoforms impacts the balance between cell self-renewal and differentiation in vitro and in vivo. METHODS...

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PMID: 17503961
DOI: 10.1371/journal.pmed.0040172

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