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Article

VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic development

23 Sept 2003

Abstract excerpt

AML1/Runx1 is a frequent target of leukemia-associated gene aberration, and it encodes a transcription factor essential for definitive hematopoiesis. We previously reported that the AML1 molecules with trans-activation subdomains retained can rescue in vitro hematopoietic defects of AML1-deficient mouse embryonic stem (ES) cells when expressed by using a knock-in approach. Extending this notion to in vivo...

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PMID: 14504086
DOI: 10.1182/blood-2003-06-2109

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