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Article

Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation.

Blood - 3 Sept 2009

Migliaccio Anna Rita, Martelli Fabrizio, Verrucci Maria, Sanchez Massimo, Valeri Mauro, Migliaccio Giovanni, Vannucchi Alessandro Maria, Zingariello Maria, Di Baldassarre Angela, Ghinassi Barbara, Rana Rosa Alba, van Hensbergen Yvette, Fibbe Willem E

Abstract excerpt

Rigorously defined reconstitution assays developed in recent years have allowed recognition of the delicate relationship that exists between hematopoietic stem cells and their niches. This balance ensures that hematopoiesis occurs in the marrow under steady-state conditions. However, during development, recovery from hematopoietic stress and in myeloproliferative disorders, hematopoiesis occurs in extramedullary...

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Share to Bone Marrow
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA1 Transcription Factor

Share to Gene Expression Regulation

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Share to Mice, Mutant Strains

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Source

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Identifiers

PMID: 19571316
DOI: 10.1182/blood-2009-03-211680
PMCID: PMC2744572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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