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Article

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.

Human molecular genetics - 15 Mar 2010

Dowdy Christopher R, Xie Ronglin, Frederick Dana, Hussain Sadiq, Zaidi Sayyed K, Vradii Diana, Javed Amjad, Li Xiangen, Jones Stephen N, Lian Jane B, van Wijnen Andre J, Stein Janet L, Stein Gary S

Abstract excerpt

Runx1 is a key hematopoietic transcription factor required for definitive hematopoiesis and is a frequent target of leukemia-related chromosomal translocations. The resulting fusion proteins, while retaining DNA binding activity, display loss of subnuclear targeting and associated transactivation functions encoded by the C-terminus of the protein. To define the precise contribution of the Runx1 C-terminus in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20035012
DOI: 10.1093/hmg/ddp568
PMCID: PMC2830828

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