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Article

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.

Blood - 15 Apr 2010

Bee Thomas, Swiers Gemma, Muroi Sawako, Pozner Amir, Nottingham Wade, Santos Ana Cristina, Li Pik-Shan, Taniuchi Ichiro, de Bruijn Marella F T R

Abstract excerpt

The transcription factor Runx1 is a pivotal regulator of definitive hematopoiesis in mouse ontogeny. Vertebrate Runx1 is transcribed from 2 promoters, the distal P1 and proximal P2, which provide a paradigm of the complex transcriptional and translational control of Runx1 function. However, very little is known about the biologic relevance of alternative Runx1 promoter usage in definitive hematopoietic cell...

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PMID: 20139099
DOI: 10.1182/blood-2009-08-238626

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Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.PMID 20139099Read ↗

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