Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signaling

doi:10.1111/j.1349-7006.2008.00842.x

Article

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signaling

30 Apr 2008

Abstract excerpt

Evi-1 is a zinc-finger transcriptional factor whose inappropriate expression leads to leukemic transformation in mice and humans. Recently, it has been shown that Evi-1 regulates proliferation of hematopoietic stem/progenitor cells at embryonic stage via GATA-2 up-regulation; however, detailed mechanisms underlying Evi-1-mediated early hematopoiesis are not fully understood. We therefore evaluated hematopoietic...

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