Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.

Developmental biology - 1 Apr 2000

Mukouyama Y, Chiba N, Hara T, Okada H, Ito Y, Kanamaru R, Miyajima A, Satake M, Watanabe T

Abstract excerpt

We examined the role of the AML1 transcription factor in the development of hematopoiesis in the paraaortic splanchnopleural (P-Sp) and the aorta-gonad-mesonephros (AGM) regions of mouse embryos. The activity of colony-forming units of colonies from the P-Sp/AGM region was reduced severalfold by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Colony-Forming Units Assay
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Gonads

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Proto-Oncogene Proteins c-myb

Source

Identifiers

PMID: 10720428
DOI: 10.1006/dbio.2000.9617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10720428-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.PMID 10720428Read ↗

The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region.Semantic proximity Read ↗

Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.Semantic proximity Read ↗

Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafishSemantic proximity Read ↗

Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.Semantic proximity Read ↗

Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.Semantic proximity Read ↗

Requirement of gp130 signaling for the AGM hematopoiesis.Semantic proximity Read ↗

Evi‐1 promotes para‐aortic splanchnopleural hematopoiesis through up‐regulation of GATA‐2 and repression of TGF‐b signalingSemantic proximity Read ↗

Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene.Semantic proximity Read ↗

The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells.Semantic proximity Read ↗

Hypoxia affects mesoderm and enhances hemangioblast specification during early development.Semantic proximity Read ↗

Aorta-associated CD34+ hematopoietic cells in the early human embryoSemantic proximity Read ↗

Development of hematopoietic cells lacking transcription factor GATA-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.