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Article

Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling.

The Journal of biological chemistry - 12 Dec 2003

Slessareva Janna E, Ma Hongzheng, Depree Karyn M, Flood Lori A, Bae Hyunsu, Cabrera-Vera Theresa M, Hamm Heidi E, Graber Stephen G

Abstract excerpt

The molecular basis of selectivity in G-protein receptor coupling has been explored by comparing the abilities of G-protein heterotrimers containing chimeric Galpha subunits, comprised of various regions of Gi1alpha, Gtalpha, and Gqalpha, to stabilize the high affinity agonist binding state of se...

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Source

Identifiers

PMID: 14525988
DOI: 10.1074/jbc.M304417200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14525988-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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