Article
Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation.
Molecular pharmacology - 1 Oct 1996
Conklin B R, Herzmark P, Ishida S, Voyno-Yasenetskaya T A, Sun Y, Farfel Z, Bourne H R
Abstract excerpt
The carboxyl terminus of the G protein alpha subunit is a key determinant of the fidelity of receptor activation. We have previously shown that the Gq alpha subunit (alpha q) can be made to respond to alpha i-coupled receptors by replacing its carboxyl terminus with the corresponding alpha i2, alpha o, alpha z residues. We now extend these findings in three ways: 1) carboxyl-terminal mutations of alpha q/alpha i...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.