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Article

Structural basis of G protein-coupled receptor-G protein interactions.

Nature chemical biology - 1 Jul 2010

Hu Jianxin, Wang Yan, Zhang Xiaohong, Lloyd John R, Li Jian Hua, Karpiak Joel, Costanzi Stefano, Wess Jürgen

Abstract excerpt

The interaction of G protein-coupled receptors (GPCRs) with heterotrimeric G proteins represents one of the most fundamental biological processes. However, the molecular architecture of the GPCR-G protein complex remains poorly defined. In the present study, we applied a comprehensive GPCR-G protein alpha subunit (Galpha) chemical cross-linking strategy to map a receptor-Galpha interface, both before and after...

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Identifiers

PMID: 20512139
DOI: 10.1038/nchembio.385
PMCID: PMC3104732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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