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Article

A surface-exposed region of G(salpha) in which substitutions decrease receptor-mediated activation and increase receptor affinity.

Molecular pharmacology - 1 Jun 2000

Grishina G, Berlot C H

Abstract excerpt

The mechanism by which receptors activate G proteins is unclear because a connection between the receptor and the nucleotide binding site has not been established. To investigate this mechanism, we evaluated the roles in receptor interaction of three potential receptor contact sites in alpha(s): the alpha2/beta4, alpha3/beta5, and alpha4/beta6 loops. Substitutions of alpha(i2) homologs for alpha(s) residues in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10825378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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