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Article

Mechanisms of dominant negative G-protein alpha subunits.

Journal of neuroscience research - 1 Dec 2007

Barren Brandy, Artemyev Nikolai O

Abstract excerpt

G-protein-coupled receptors (GPCRs) represent the largest class of membrane proteins and are the targets of 25-50% of drugs currently on the market. Dominant negative mutant Galpha subunits of heterotrimeric G-proteins have been extensively utilized to delineate G-protein signaling pathways and represent a promising new tool to study GPCR-dependent signaling in the CNS. There are different regions in various...

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Identifiers

PMID: 17639598
DOI: 10.1002/jnr.21414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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