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Article

pRb, Myc and p53 are critically involved in SV40 large T antigen repression of PDGF beta-receptor transcription.

Journal of cell science - 1 Aug 2004

Uramoto Hidetaka, Hackzell Anders, Wetterskog Daniel, Ballági Andrea, Izumi Hiroto, Funa Keiko

Abstract excerpt

The expression of the PDGF beta-receptor is tightly regulated during a normal cell cycle. c-Myc and p73alpha repress transcription of the receptor through interaction with NF-Y. In ST15A cells which stably express the temperature-sensitive SV40 large T antigen (LT) the receptor expression and ligand binding decreased under the permissive condition. Transient expression of the LT, but not small t, decreased the...

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Identifiers

PMID: 15265983
DOI: 10.1242/jcs.01228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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