LUCA15, a putative tumour suppressor gene encoding an RNA‐binding nuclear protein, is down‐regulated in ras‐transformed Rat‐1 cells

Abstract excerpt

BACKGROUND: The proliferation of mammalian cells is controlled by various intracellular mitogenic signalling pathways. In the intracellular pathways, Ras is involved in the activation of proto-oncogenes such as an immediate early gene c-fos. The somatic mutations of ras genes that elicit the constitutive activation of Ras have been found in tumours. Although these findings suggest that the constitutive activation...

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