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Article

Negative regulation of the neu promoter by the SV40 large T antigen.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1993

Matin A, Hung M C

Abstract excerpt

The neu gene is amplified and its protein product is overexpressed in certain human tumors. The adenovirus 5 E1a gene product and c-myc repress neu transcription. Moreover, expression of E1a in neu-transformed cells leads to decrease in transformation phenotype and metastatic potential. The simian virus 40 large T antigen (LT) shares structural and functional homology with E1a and c-myc, and all three proteins...

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Share to Promoter Regions, Genetic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to ErbB Receptors

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Source

Identifiers

PMID: 7906953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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