Negative regulation of the neu promoter by the SV40 large T antigen.

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Article

Negative regulation of the neu promoter by the SV40 large T antigen.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1993

Matin A, Hung M C

Abstract excerpt

The neu gene is amplified and its protein product is overexpressed in certain human tumors. The adenovirus 5 E1a gene product and c-myc repress neu transcription. Moreover, expression of E1a in neu-transformed cells leads to decrease in transformation phenotype and metastatic potential. The simia...

Topics

Animals
Antigens, Polyomavirus Transforming
Cells, Cultured
Chloramphenicol O-Acetyltransferase
ErbB Receptors
Gene Expression Regulation
Mice
Mutation
Promoter Regions, Genetic
Proto-Oncogene Proteins
Rats
Receptor, ErbB-2
Retinoblastoma Protein

Source

Open in PubMed

Identifiers

PMID: 7906953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7906953-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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