p53 suppresses cytokine induced, Stat5 mediated activation of transcription.

doi:10.1016/s0303-7207(98)00140-3

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Article

p53 suppresses cytokine induced, Stat5 mediated activation of transcription.

Molecular and cellular endocrinology - 25 Aug 1998

Fritsche M, Mundt M, Merkle C, Jähne R, Groner B

Abstract excerpt

p53 is a tumor suppressor which exerts its function through the regulation of genes mediating cell cycle arrest and the induction of apoptosis. Cellular survival and proliferation can be positively regulated through the action of cytokines. These signals act through the activation of cell surface...

Topics

Animals
COS Cells
Cytokines
DNA-Binding Proteins
Genes, Tumor Suppressor
Milk Proteins
Mutation
STAT5 Transcription Factor
Signal Transduction
Trans-Activators
Transcriptional Activation
Tumor Suppressor Protein p53

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