Article
Interactions among Janus kinases and the prolactin (PRL) receptor in the regulation of a PRL response element.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1996
Gao J, Hughes J P, Auperin B, Buteau H, Edery M, Zhuang H, Wojchowski D M, Horseman N D
Abstract excerpt
PRL regulates milk gene expression, at least in part, by activating JAK2 kinase and STAT5 (signal transducer and activator of transcription 5), initially termed mammary gland factor (MGF). These experiments were initiated to gain a better understanding of the mechanisms of transcriptional activation via PRL receptor (PRL-R) signaling. Binding of PRL to the recombinant pigeon PRL-R-activated transcription driven...
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