Article
Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene.
Biochemical and biophysical research communications - 5 Oct 2000
Yam J W, Chan K W, Li N, Hsiao W L
Abstract excerpt
Rat nonmuscle myosin heavy chain-B (r-nmMHC-B) mRNA was previously found downregulated in Rat 6 fibroblasts transformed by mutant p53(val135) [J. W. P. Yam, J. Y. Zheng, and W. L. W. Hsiao (1987) Biochem. Biophys. Res. Commun. 266, 472-480]. Overexpression of exogenous r-nmMHC-B could partially reverse the transforming phenotypes both in vitro and in vivo. The downregulation of r-nmMHC-B was also observed in Rat...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Conserved Sequence
- Fibroblasts
- Gene Expression Regulation
- Genes, Reporter
- Genes, myc
- Genes, p53
- Genes, ras
- Humans