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Article

Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes.

Journal of neuroscience research - 15 Aug 2004

Pocernich Chava B, Sultana Rukhsana, Hone Eugene, Turchan Jadwiga, Martins Ralph N, Calabrese Vittorio, Nath Avindra, Butterfield D Allan

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1)-associated dementia is observed in 20-30% of patients with acquired immunodeficiency syndrome (AIDS). The epsilon4 allele of the apolipoprotein E (APOE) gene currently is thought to play a role as a risk factor for the development of HIV dementia. The HIV protein Tat is neurotoxic and binds to the same receptor as apoE, the low-density lipoprotein receptor-related...

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Share to AIDS Dementia Complex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, tat

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Share to tat Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 15264223
DOI: 10.1002/jnr.20182

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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