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Article

HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.

Experimental neurology - 1 Oct 2013

Bertrand Sarah J, Aksenova Marina V, Mactutus Charles F, Booze Rosemarie M

Abstract excerpt

HIV-1 enters the central nervous system early in infection; although HIV-1 does not directly infect neurons, HIV-1 may cause a variety of neurological disorders. Neuronal loss has been found in HIV-1, but synaptodendritic injury is more closely associated with the neurocognitive disorders of HIV-1. The HIV-1 transactivator of transcription (Tat) protein causes direct and indirect damage to neurons. The cysteine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23811015
DOI: 10.1016/j.expneurol.2013.06.020
PMCID: PMC3773475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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