Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging

Abstract excerpt

HIV infects the central nervous system and causes HIV/neuroAIDS, which is predominantly manifested in the form of mild cognitive and motor disorder in the era of combination antiretroviral therapy. HIV Tat protein is known to be a major pathogenic factor for HIV/neuroAIDS through a myriad of direct and indirect mechanisms. However, most, if not all of studies involve short-time exposure of recombinant Tat protein...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV-related health complications and treatments
• Share to HIV Research and Treatment
• Share to Neuroinflammation and Neurodegeneration Mechanisms