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Article

HIV-1 and HIV-1-Tat Induce Mitochondrial DNA Damage in Human Neurons

1 Jan 2020

Abstract excerpt

INTRODUCTION: Mitochondrial dysregulation is a key event in HIV-1 infection. Recent studies have suggested that age-related neurodegenerative disorders are associated with increased mitochondrial DNA (mtDNA) damage. As accelerated ageing was found in HIV-1 patients, we hypothesized that HIV-1 infection or HIV-1 proteins can lead to mtDNA damage. Unrepaired mtDNA impairs mitochondrial function, which can lead to...

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PMID: 33506104
DOI: 10.16966/2380-5536.176

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