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Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants

28 Jan 2003

Abstract excerpt

OBJECTIVE: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS: Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation. Oxidized proteins in CSF of patients with various stages of HIV dementia were quantitated and...

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PMID: 12552050
DOI: 10.1212/01.wnl.0000042048.85204.3d

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