Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal.

Journal of neurochemistry - 1 Apr 2000

Pedersen W A, Chan S L, Mattson M P

Abstract excerpt

Inheritance of the apolipoprotein E (apoE) epsilon4 allele increases the risk for Alzheimer's disease and may also influence the pathogenesis of other neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). The influence of apoE genotype on disease susceptibility must ultimately be explained by the fact that apoE proteins differ in only two amino acids: apoE2 has two cysteine residues, apoE3 has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehydes
Share to Amyloid beta-Peptides
Share to Cysteine Proteinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isomerism

Share to Lipid Peroxidation

Share to Neurodegenerative Diseases

Share to Neuroprotective Agents

Share to Spinal Cord

Source

Identifiers

PMID: 10737598
DOI: 10.1046/j.1471-4159.2000.0741426.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal.PMID 10737598Read ↗

Detrimental Effects of Apolipoprotein E4: Potential Therapeutic Targets in Alzheimers DiseaseSemantic proximity Read ↗

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.Semantic proximity Read ↗

Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner.Semantic proximity Read ↗

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.Semantic proximity Read ↗

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides.Semantic proximity Read ↗

In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology.Semantic proximity Read ↗

The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA).Semantic proximity Read ↗

Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 mice.Semantic proximity Read ↗

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.Semantic proximity Read ↗

APOE genotype-specific differences in the innate immune response.Semantic proximity Read ↗

Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype.Semantic proximity Read ↗

4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.