Article
Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.
Neurobiology of disease - 1 Jul 2006
Turchan-Cholewo Jadwiga, Liu Yiling, Gartner Suzanne, Reid Rollie, Jie Chunfa, Peng Xuejun, Chen Kuey Chu C, Chauhan Ashok, Haughey Norman, Cutler Roy, Mattson Mark P, Pardo Carlos, Conant Katherine, Sacktor Ned, McArthur Justin C, Hauser Kurt F, Gairola Chandra, Nath Avindra
Abstract excerpt
Human immunodeficiency virus (HIV) infection continues to rise in drug-abusing populations and causes a dementing illness in a subset of individuals. Factors contributing to the development of dementia in this population remain unknown. We found that HIV-infected individuals with the E4 allele of Apolipoprotein E (ApoE) or history of intravenous drug abuse had increased oxidative stress in the CNS. In vitro...
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