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Article

Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner.

Brain research - 4 Jan 2002

Lauderback Christopher M, Kanski Jaroslaw, Hackett Janna M, Maeda Noboyo, Kindy Mark S, Butterfield D Allan

Abstract excerpt

Several functional differences have been reported among the three human e2, e3, and e4 alleles of apolipoprotein E (apoE). One functional difference lies in the antioxidant potential of these alleles; e4 has the poorest potential. Interestingly, e4 also correlates with increased oxidative damage in the Alzheimer's disease (AD) brain, which may explain why the inheritance of the e4 allele is a risk factor for the...

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Identifiers

PMID: 11743999
DOI: 10.1016/s0006-8993(01)03228-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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